Mending broken hearts: siRNA-based therapies administered during ex vivo heart perfusion for organ optimization

J. E.. Buchwald¹, H. H.. Fakih¹, C. E.. Tocheny², M. Bolger-Chen³, M. Lopera Higuita⁴, W. Michaud⁵, R. N.. Pierson III⁶, A. A.. Osho⁷, S. Tessier⁴, A. Khvorova¹, S. Rabi^8
1RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA, Worcester, Massachusetts ²Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA, Worcester, Massachusetts ³Massachusetts General Hospital/Shriners Children's Boston, Boston, Massachusetts ⁴Center for Engineering in Medicine and Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA, Boston, Massachusetts ⁵Division of Cardiac Surgery, Massachusetts General Hospital,, Boston, Massachusetts ⁶Center for Transplantation Sciences, Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Boston, Massachusetts ⁷Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Boston, Massachusetts ⁸Massachusetts General Hospital, Division of Cardiac Surgery, Boston, Massachusetts