1. Centre for Molecular Therapeutics, Department of Biomedical Science and Molecular Biology, Australian Institute of Tropical Medicine and Health, College of Public Health, Medical and Veterinary Sciences, College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia. 2.Department of Cardiothoracic Surgery, Townsville University Hospital, PO Box 670, Townsville, Queensland, 4810, Australia., Australia